Sea Bed Sand Waves Studied To Help Pipeline Planners

The article cites a study that offers information on the variability of sand wave characteristics in the North Sea. The sand waves variability includes a statement that pipelines may start vibrating due to turbulence generated under the free span and navigational channels often need to be dredged for ships to pass safely. The study used multi-beam measurement of three fields in the North Sea in which sand waves occur. Moreover, the study concludes that understanding the variability of sand waves can help determine the optimal depth of a pipeline trench

High-Performance Deep SubMicron CMOS Technologies with Polycrystalline-SiGe Gates

The use of polycrystalline SiGe as the gate material for deep submicron CMOS has been investigated. A complete compatibility to standard CMOS processing is demonstrated when polycrystalline Si is substituted with SiGe (for Ge fractions below 0.5) to form the gate electrode of the transistors. Performance improvements are achieved for PMOS transistors by careful optimization of both transistor channel profile and p-type gate workfunction, the latter by changing Ge mole fraction in the gate. For the 0.18 ¿m CMOS generation we record up to 20% increase in the current drive, a 10% increase in the channel transconductance and subthreshold swing improvement from 82 mV/dec to 75 mV/dec resulting in excellent ¿on¿/¿off¿ currents ratio. At the same time, NMOS transistor performance is not affected by gate material substitutio

Enkele beschouwingen over het gezinsloon

Proefschrift--Vrije universiteit te Amsterdam.Mode of access: Internet

De definitie van specialistische geneesmiddelen

Samenvatting Vanwege bekostigingsproblemen met bepaalde geneesmiddelen is er een afbakeningsdiscussie rond dit onderwerp ontstaan. Buiten het ziekenhuis worden soms geneesmiddelen gebruikt waarvan zorgverzekeraars vinden dat ze niet via de extramurale geneesmiddelfinanciering moeten worden bekostigd maar dat ze ten laste van het ziekenhuisbudget zouden moeten komen. Ziekenhuizen zijn bereid deze geneesmiddelen te betalen als ze er maar voor gecompenseerd worden. Tegen deze achtergrond is een mogelijke oplossing voor de financieringsproblematiek om extramuraal afgeleverde geneesmiddelen te scheiden in specialistische en generalistische middelen. Door de specialistische geneesmiddelen medisch-inhoudelijk, beleidsmatig en financieel onder de reikwijdte van het ziekenhuis te brengen kan de continuïteit in behandeling door de medisch specialist ook worden doorgetrokken naar de farmacotherapie, ongeacht waar de patiënt zich bevindt (intramuraal of extramuraal). Voor generalistische middelen zou de medisch-inhoudelijke, beleidsmatige en financiële praktijk niet anders zijn dan in de huidige situatie. etc ..

Role of queen promiscuity in reproductive swarming by honey bees

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Mapping onto Eq-5 D for patients in poor health

<p>Abstract</p> <p>Background</p> <p>An increasing amount of studies report mapping algorithms which predict EQ-5 D utility values using disease specific non-preference-based measures. Yet many mapping algorithms have been found to systematically overpredict EQ-5 D utility values for patients in poor health. Currently there are no guidelines on how to deal with this problem. This paper is concerned with the question of why overestimation of EQ-5 D utility values occurs for patients in poor health, and explores possible solutions.</p> <p>Method</p> <p>Three existing datasets are used to estimate mapping algorithms and assess existing mapping algorithms from the literature mapping the cancer-specific EORTC-QLQ C-30 and the arthritis-specific Health Assessment Questionnaire (HAQ) onto the EQ-5 D. Separate mapping algorithms are estimated for poor health states. Poor health states are defined using a cut-off point for QLQ-C30 and HAQ, which is determined using association with EQ-5 D values.</p> <p>Results</p> <p>All mapping algorithms suffer from overprediction of utility values for patients in poor health. The large decrement of reporting 'extreme problems' in the EQ-5 D tariff, few observations with the most severe level in any EQ-5 D dimension and many observations at the least severe level in any EQ-5 D dimension led to a bimodal distribution of EQ-5 D index values, which is related to the overprediction of utility values for patients in poor health. Separate algorithms are here proposed to predict utility values for patients in poor health, where these are selected using cut-off points for HAQ-DI (> 2.0) and QLQ C-30 (< 45 average of QLQ C-30 functioning scales). The QLQ-C30 separate algorithm performed better than existing mapping algorithms for predicting utility values for patients in poor health, but still did not accurately predict mean utility values. A HAQ separate algorithm could not be estimated due to data restrictions.</p> <p>Conclusion</p> <p>Mapping algorithms overpredict utility values for patients in poor health but are used in cost-effectiveness analyses nonetheless. Guidelines can be developed on when the use of a mapping algorithms is inappropriate, for instance through the identification of cut-off points. Cut-off points on a disease specific questionnaire can be identified through association with the causes of overprediction. The cut-off points found in this study represent severely impaired health. Specifying a separate mapping algorithm to predict utility values for individuals in poor health greatly reduces overprediction, but does not fully solve the problem.</p